Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts

Background: Marine microorganisms such as algae were identified a rich sources of biologically active compounds. This study was designed to explore the in vitro antioxidant, anti-apoptotic and anti proliferative activities of different algae [Gracilaria dendroides (GD), Dictyota ciliolata (DC) and Cladophora socialis (CS)] extracts obtained from Red sea at Jeddah.

Materials and Methods: Algae extracts (ethanol, chloroform and water) were tested for antioxidant activity for free radical scavenging and secondly as anti-apoptotic and anti-proliferative activity against different cell lines. Antioxidant capacity was detected by evaluation superoxide anion radicals, reducing potential and assay of phenolic and flavonoid content in extracts.

Results: Chloroform extract of DC (CEDC) was found to have a better free radical scavenging activity (IC50= 310.58 g/ml) than methanol extract (MEDC). MEDC (IC50= 522 g/ml). The phenol level in CEDC and MEDC were 50.1 and 38.18 mg, while flavonoids were 65.58and 41.74 /mg.EDC and EDC were showed ant proliferative against MC7 and HALA 1.

Conclusion: The solvents extracts exhibited promising biological activity as antioxidants and ant proliferative action.