Siegel, Steven J. and Nagy, Lauren and Skarsfeldt, Torben and Pierce, Mark and Neill, Carol O’ and Lin, Robert and Langhamer, Lori and Kordower, Jeffery H. (2013) Ropinirole Implants Reverse MPTP-Induced Parkinsonism in Rhesus Monkeys. Pharmacology & Pharmacy, 04 (03). pp. 1-8. ISSN 2157-9423
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Abstract
Purpose: We compared efficacy and side effects of ropinirole implants with oral ropinirole in parkinsonian monkeys. Methods: Twenty monkeys received injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloride (MPTP) to render them parkinsonian. Monkeys were then placed into 3 groups based upon clinical rating scores (CRS). Group 1 received oral ropinirole and placebo implants. Group 2 receivedropinirole implants that released 1/9th of the animals’ optimal daily oral dose and oral placebo. Group 3 received placebo implants and oral placebo. Monkeys were assessed for pharmacokinetic data, CRS, Global Dyskinesia Rating Scale, and skin irritation. Results: For the ropinirole implant group, the activity pattern was similar to that seen pre-MPTP; which extended through the weekends and was greater than control treated parkinsonian monkeys. Oral ropinirole yielded a high degree of variability for activity, with values following oral dosing being higher than the pre-MPTP periodbut levels similar to placebo treated parkinsonian animals during weekends, which were excluded from oral dosing. Implants and oral treatment achieved significant improvement in CRS between 11 - 60 days and 4 - 60 days respectively. Conclusion: Low dose ropinirole implants have the potential to provide continuous clinical improvement in bradykinesia with fewer “off periods” and lower risk for medication-induced psychosis than oral medication.
Item Type: | Article |
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Subjects: | Digital Academic Press > Chemical Science |
Depositing User: | Unnamed user with email support@digiacademicpress.org |
Date Deposited: | 27 Feb 2023 08:56 |
Last Modified: | 24 Jun 2024 04:42 |
URI: | http://science.researchersasian.com/id/eprint/519 |