The Effects of Antiepileptic Drugs (AED) on Serum Copper Level in Children with Epilepsy

., Shamim-Ara-Sarkar and Rahman, Habibur and Jahan, Israt and Ahmed, Md. Ranzu (2019) The Effects of Antiepileptic Drugs (AED) on Serum Copper Level in Children with Epilepsy. Journal of Pharmaceutical Research International, 27 (2). pp. 1-7. ISSN 2456-9119

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Abstract

Background: Epilepsy is a central nervous system disorder in which brain activity becomes irregular, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. Serum copper level may change due to long term use of antiepileptic drugs.

Objective: The purpose of the present study was to assess the serum copper level in childhood epilepsy treated with long-term Anti-Epileptic Drug (AED).

Methodology: This cross-sectional study was carried out in the Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during March to August’ 2013. Sample size was one hundred, among these fifty were case (epileptic child who had received anti-epileptic drugs (Carbamazepine and/or Valproic acid) for more than three months) and rest fifty were control (newly diagnosed epileptic child, who yet not received antiepileptic drug).

Result: The mean copper level was 1.11±0.32 µg/ml in case group and 0.96±0.20 µg/ml in control group, which was statistically significant (p<0.05).

Conclusion: The use of one drug or multiple drugs in the treatment of epileptic patients may play significant role in increasing copper serum level.

Item Type: Article
Subjects: Digital Academic Press > Medical Science
Depositing User: Unnamed user with email support@digiacademicpress.org
Date Deposited: 28 Apr 2023 05:50
Last Modified: 17 Jun 2024 06:40
URI: http://science.researchersasian.com/id/eprint/930

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